In the pharmaceutical industry, maintaining a controlled environment free from contamination is paramount, and two common processes used for this purpose are fumigation and fogging. While both serve the same ultimate goal, there are significant differences between them, with fogging emerging as a safer alternative to fumigation.
Fumigation involves the mixing of a formaldehyde solution with potassium permanganate in specific proportions. This combination generates fumes that are highly effective in eliminating bacteria, fungi, and their spores. It is a preferred method for contamination control in many settings.
On the other hand, fogging employs a mixture of hydrogen peroxide and a silver ion solution to combat contamination. A fogger machine is used to disperse this solution throughout the controlled area effectively. Various disinfectants can be used for fogging, but hydrogen peroxide and silver ion solutions are among the most commonly chosen.
In recent times, fogging has gained prominence over fumigation, primarily due to the adverse side effects associated with the latter. Fumigation employs formaldehyde solution, a substance known to be carcinogenic or cancer-causing. Users are at risk of exposure to cancer, and this is a significant reason why fumigation is prohibited in some pharmaceutical facilities. Additionally, formaldehyde solution can cause irritation in the eyes and nose, dizziness, and nausea.
Apart from these negative side effects, fumigation necessitates extensive cleanup after the process is completed. De-fumigation is required in the controlled area, often involving the use of an air handling unit (AHU) running continuously for several hours to remove residual fumes from the air. Cleaning and sanitizing the equipment and the area are also mandatory post-fumigation.
In contrast, fogging is a much safer process. A fogger machine disperses the hydrogen peroxide and silver ion solution in aerosol form within the controlled area. Personnel handling the equipment face no risks, and there is no need for additional tasks such as cleaning, mopping, or de-fogging. The residues in the air decompose naturally with the presence of water and nascent oxygen.
In conclusion, fogging emerges as the superior and safer method for controlling contamination in pharmaceutical settings. The stark contrast between the two processes makes fogging the preferred choice, as it ensures the safety of personnel and eliminates the need for extra measures. Hydrogen peroxide and silver ion solutions effectively eliminate bacteria and fungi without the drawbacks associated with fumigation, where constant attention is required to keep both the area and equipment handlers safe. Therefore, fogging is the preferred option between the two.