Coaching This article serves as a detailed guide to the Standard Operating Procedure (SOP) for the cleaning and operation of static pass boxes in controlled environments. Recognizing the critical role these boxes play in preventing cross-contamination in cleanrooms, the SOP outlined here emphasizes meticulous cleaning protocols and precise operational steps. Covering everything from routine maintenance to best practices during operation, this guide empowers professionals in pharmaceuticals, biotechnology, and other industries to uphold stringent cleanliness standards, ensuring the integrity of their controlled environments.