Services This abstract discusses measures to address common regulatory compliance challenges in pharmaceutical manufacturing, including poor investigations, absence of written procedures, data integrity issues, and cleaning, sanitizing, and maintenance deficiencies. Root cause analysis, enhanced documentation, data integrity controls, and training are essential to remediate discrepancies and failures effectively. Additionally, robust procedures, competency training, and continuous improvement foster a culture of compliance and quality. By implementing these measures comprehensively, pharmaceutical manufacturers can ensure regulatory compliance, product quality, and patient safety.